Реакция #66848

Уравнение реакции

1-(3-fluorobenzyl)-1H-indazol-5-amine

1-(3-Fluorobenzyl)-1H-indazol-5-amine

tert-butyl 4-chloro-3-cyano-5,8-dihydrothieno[2,3-b:5,4-c′]dipyridine-7(6H)-carboxylate

tert-Butyl 4-chloro-3-cyano-5,8-dihydrothieno[2,3-b:5,4-c′]dipyridine-7(6H)-carboxylate

→

title compound

tert-Butyl 3-cyano-4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}-5,8-dihydrothieno[2,3-b:5,4-c′]-dipyridine-7(6H)-carboxylate

Условия реакции

Обработка

1. 1
   Другоеto yield 234 mg (74%)

Методика

In analogy to Example 54A, the title compound was synthesized from 1-(3-fluorobenzyl)-1H-indazol-5-amine from Example 8A (138 mg, 0.57 mmol) and tert-butyl 4-chloro-3-cyano-5,8-dihydrothieno[2,3-b:5,4-c′]dipyridine-7(6H)-carboxylate (200 mg, 0.57 mmol) from Example 53A to yield 234 mg (74%).

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