Реакция #66789

Уравнение реакции

1-(3-Fluorobenzyl)-5-nitro-1H-indazole

→

title compound

Выход 64.5%

1-(3-Fluorobenzyl)-1H-indazol-5-amine

Выход 64.5%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ДругоеAfter removal of the solvent and trituration with tert-butyl methyl ether

Методика

1-(3-Fluorobenzyl)-5-nitro-1H-indazole from Example 7A (500 mg) was dissolved in ethanol (40 mL) and was hydrogenated in an H-Cube™ (room temperature, 1 bar, 1 mL/min, 10% Pd/C catalyst). After removal of the solvent and trituration with tert-butyl methyl ether, 287 mg (64%) of the title compound were obtained.

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