Реакция #66751

Уравнение реакции

5-bromo-2-hydroxyacetophenone

N-Boc-piperidin-4-one

pyrrolidine

MeOH

→

tert-Butyl 6-bromo-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate

Растворители

H2O

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураunder reflux until the reaction
3. 3
   ТемператураThe mixture was cooled
4. 4
   Фильтрацияthe mixture was filtered
5. 5
   Другоеdried
6. 6
   Другоеto give

Методика

A mixture of 5-bromo-2-hydroxyacetophenone (104 g, 485 mmol), N-Boc-piperidin-4-one (98.6 g, 494 mmol), 20 mL of pyrrolidine (17.3 g, 243 mmol) and 261 mL of MeOH was heated under reflux until the reaction was complete. The mixture was cooled, then 87 mL of H2O were added, and the mixture was filtered and dried to give intended compound as a colorless solid.

Источник