Реакция #66748

ord-87e6f9a9af334c1caa8640553460e833

Уравнение реакции

Cc1n[nH]c2ccc(C(=O)N3CCC4(CC3)CC(=O)c3cc(-c5cnn(C)c5)ccc3O4)cc12
1′-[(3-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-4-yl)spiro[chroman-2,4′-piperidin]-4-one
COC(=O)c1cccc(B(O)O)c1
[3-(methoxycarbonyl)phenyl]boronic acid
COC(=O)c1ccc(B(O)O)cc1
[4-(methoxycarbonyl)phenyl]boronic acid
COC(=O)c1cccc(-n2nc(C)c3cc(C(=O)N4CCC5(CC4)CC(=O)c4cc(-c6cnn(C)c6)ccc4O5)ccc32)c1
Methyl 3-(3-methyl-5-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4′-piperidin]-1′yl]carbonyl}-1H-indazol-1-yl)benzoate

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    ДругоеThe intended compound was produced

Методика

The intended compound was produced according to the procedure described in Example 28-2 but using 1′-[(3-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-4-yl)spiro[chroman-2,4′-piperidin]-4-one and [3-(methoxycarbonyl)phenyl]boronic acid in place of 1′-[(3-methyl-1H-indazol-6-yl)carbonyl]-6-(1-methyl-1H-pyrazol-4-yl)spiro[chroman-2,4′-piperidin]-4-one and [4-(methoxycarbonyl)phenyl]boronic acid.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08524730B2uspto-grants-2013_09