Реакция #6673

Уравнение реакции

phenothiazine

iodoethane

potassium hydroxide

→

10-Ethylphenothiazine

Растворители

toluene

Условия реакции

Обработка

1. 1
   Температураwas refluxed for 24 hours
2. 2
   ТемператураAfter cooling
3. 3
   Фильтрацияthe reaction mixture was filtered
4. 4
   Другоеthe solvent was evaporated
5. 5
   ДругоеThe product was crystallized from methanol

Методика

A mixture of 10 g (0.05 mol) of phenothiazine, 11.7 g (0.075 mol) of iodoethane, 4.2 g (0.075 mol) of potassium hydroxide and 0.25 g of tetra-n-butylammonium hydrogen sulfate in 200 ml of dry toluene was refluxed for 24 hours. After cooling, the reaction mixture was filtered, and the solvent was evaporated. The product was crystallized from methanol. The yield of 10-ethylphenothiazine (C14H13NS, FW=227.33) was 90%.

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