Реакция #66653

Уравнение реакции

NH3

4-Chloro-5-(5-chloro-2-isopropyl-4-methoxy-benzyl)-2-methylsulfanyl-pyrimidine

→

5-(5-chloro-2-isopropyl-4-methoxy-benzyl)-2-methylsulfanyl-pyrimidin-4-ylamine

Выход 92.0%

Растворители

EtOH

Условия реакции

Обработка

1. 1
   ТемператураAfter 3 days the solution was cooled
2. 2
   Концентрированиеconcentrated in vacuo
3. 3
   ФильтрацияThe precipitate was filtered
4. 4
   Концентрированиеthe mother liquor was concentrated in vacuo
5. 5
   ДругоеPurification via flash chromatography (7:3 hexane/ethyl acetate)

Методика

To 25 ml of saturated NH3 in EtOH was added 4-Chloro-5-(5-chloro-2-isopropyl-4-methoxy-benzyl)-2-methylsulfanyl-pyrimidine (0.580 g, 1.6 mmol). The solution was warmed to 85° C. in a sealed reaction vessel. After 3 days the solution was cooled, concentrated in vacuo and suspended in CH2Cl2. The precipitate was filtered and the mother liquor was concentrated in vacuo. Purification via flash chromatography (7:3 hexane/ethyl acetate) afforded 5-(5-chloro-2-isopropyl-4-methoxy-benzyl)-2-methylsulfanyl-pyrimidin-4-ylamine (0.504 g, 92%) as a white solid.

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