Реакция #66513

Уравнение реакции

4-iodo-1H-pyrazole

1-(chloromethyl)-4-methoxybenzene

K2CO3

→

4-iodo-1-(4-methoxybenzyl)-1H-pyrazole

Выход 88.2%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   ТемператураThe reaction mixture was cooled to room temperature
2. 2
   Фильтрацияwas filtered
3. 3
   КонцентрированиеThe filtrate was concentrated under reduced pressure
4. 4
   ДругоеThe crude product was purified by flash chromatography over silica gel

Методика

According to Scheme 6 Step 1: A suspension of 4-iodo-1H-pyrazole (26.3 mmol, 5.11 g), 1-(chloromethyl)-4-methoxybenzene (29.0 mmol, 3.95 mL) and K2CO3 (39.5 mmol, 5.46 g) in acetonitrile (150 mL) was heated at 60° C. overnight. The reaction mixture was cooled to room temperature and was filtered. The filtrate was concentrated under reduced pressure. The crude product was purified by flash chromatography over silica gel using DCM as eluent to afford 4-iodo-1-(4-methoxybenzyl)-1H-pyrazole (23.2 mmol, 7.3 g, 88%) as a yellow solid.

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