Реакция #66511

Уравнение реакции

1-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-bromoethanone

potassium cyanide

→

3-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-3-oxopropanenitrile

Выход 97.0%

Растворители

water

water MeOH THF

Условия реакции

Обработка

1. 1
   Экстракцияthe aqueous phase was extracted with DCM
2. 2
   СушкаThe organic phase was dried over MgSO4
3. 3
   Фильтрацияwas filtered
4. 4
   Концентрированиеwas concentrated

Методика

According to Scheme 5 Step 1: A solution of 1-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-bromoethanone (9.70 mmol, 3.00 g) and potassium cyanide (14.6 mmol, 948 mg) in 120 mL of water/MeOH/THF (1:1:1) was stirred for 30 minutes at room temperature. The reaction mixture was diluted with water (150 mL) and the aqueous phase was extracted with DCM. The organic phase was dried over MgSO4, was filtered and was concentrated to yield 3-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-3-oxopropanenitrile (9.40 mmol, 2.40 g, 97%).

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