Реакция #66281

ord-421b41a70fa54d978afd5162a0be0f19

Уравнение реакции

CC1(C)OB(c2ccc(C(=O)O)cc2)OC1(C)C
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid
CC(C)(C)[Si](C)(C)O[C@@H]1CCNC1
(R)-3-(tert-butyldimethylsilyloxy)pyrrolidine
→
CC1(C)OB(c2ccc(C(=O)N3CC[C@@H](O[Si](C)(C)C(C)(C)C)C3)cc2)OC1(C)C
title compound
CC1(C)OB(c2ccc(C(=O)N3CC[C@@H](O[Si](C)(C)C(C)(C)C)C3)cc2)OC1(C)C
(R)-(3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone

Реактанты

CC1(C)OB(c2ccc(C(=O)O)cc2)OC1(C)C
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid
CC(C)(C)[Si](C)(C)O[C@@H]1CCNC1
(R)-3-(tert-butyldimethylsilyloxy)pyrrolidine

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

The title compound was prepared by the procedure as described in Example 101 (Step H) using 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid and (R)-3-(tert-butyldimethylsilyloxy)pyrrolidine.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08524702B2uspto-grants-2013_09