Реакция #6602

Уравнение реакции

aluminum chloride

phenol

2,5-dichloro-2,5-dimethylhexane

→

title compound

Выход 32.1%

5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthol

Выход 32.1%

Растворители

Условия реакции

Обработка

1. 1
   Экстракцияextracted with ether
2. 2
   Промывкаthe organic phase was washed
3. 3
   Сушкаdried over sodium sulfate
4. 4
   Другоеevaporated under reduced pressure
5. 5
   ДругоеTwo recrystallizations of the residue from methanol

Методика

27.5 g (0.2 mol) of anhydrous aluminum chloride were added by spatula to 250.0 g (2.65 mol) of phenol plus 414.5 g (2.27 mol) of 2,5-dichloro-2,5-dimethylhexane in 500 ml of petroleum ether at room temperature while stirring. After 48 hours, the reaction mixture was poured into ice-water and extracted with ether, and the organic phase was washed to neutrality with water, dried over sodium sulfate and evaporated under reduced pressure. Two recrystallizations of the residue from methanol yielded 148.7 g of the title compound of melting point 219°-220 C.

Источник