Реакция #65967

Уравнение реакции

1-naphthol

piperidine

formaldehyde

→

2-(piperidinomethyl)-1-naphthol

Выход 45.0%

Условия реакции

Обработка

1. 1
   Другоеthe following reaction scheme

Методика

Brown (Bull. Natl. Inst. Sci. India, No. 31, 167-178, 1965) discloses the following reaction scheme: Mannich reaction of 1-naphthol with piperidine and formaldehyde afforded 2-(piperidinomethyl)-1-naphthol in a yield of 45%. Reduction of 2-(piperidinomethyl)-1-naphthol in the presence of H2 /Pd/SrCO3 afforded 2-methyl-1-naphthol in a yield of 85%.

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