Реакция #65903

Уравнение реакции

HCl

HCl

sodium cyanide

anisaldehyde

triethylamine

→

p-methoxybenzaldehyde cyanohydrin

Растворители

ethyl alcohol

Условия реакции

Обработка

1. 1
   workup.ALIQUOTIn situ sampling of the reaction mixture
2. 2
   Другоеthe reaction
3. 3
   Другоеto quench
4. 4
   Другоеthe reaction
5. 5
   ФильтрацияtHE solution is filtered
6. 6
   Другоеused in the next step without further purification
7. 7
   ДругоеYield

Методика

To 49 g (1 mole) of sodium cyanide and 136 g (1 mole) anisaldehyde in ethyl alcohol 800 ml), containing triethylamine (5 mol %, 5.1 g) is added HCl gas (1 mol, 36.5 g) over 30 minutes at 5°-10° C. The resulting slurry is stirred at that temperature for 6 hours. In situ sampling of the reaction mixture shows the reaction to be complete. Additional HCl (0.2 moles) is added to quench the reaction. tHE solution is filtered and used in the next step without further purification. Yield, ca. 80%.

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