Реакция #65752

Уравнение реакции

2-amino-3,4-diethoxycarbonyl-6-methylpyridine

sodium nitrite

→

3,4-Diethoxycarbonyl-6-methyl-2-pyridone

Растворители

hydrochloric acid

water

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added dropwise to the solution
2. 2
   workup.WAITleft
3. 3
   Другоеstanding in a refrigerator overnight
4. 4
   ФильтрацияThe resulting crystals were collected by filtration
5. 5
   ДругоеThe crystals were recrystallized from ethyl acetate
6. 6
   Другоеto give colorless plates

Методика

In 90 ml of 2% hydrochloric acid was dissolved 2.52 g (10 mmol) of 2-amino-3,4-diethoxycarbonyl-6-methylpyridine. A solution of 0.83 g (1.2 eq.) of sodium nitrite dissolved in 3 ml of water was added dropwise to the solution. The mixture was stirred at room temperature for 1 hour and left standing in a refrigerator overnight. The resulting crystals were collected by filtration. The crystals were recrystallized from ethyl acetate to give colorless plates.

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