Реакция #65741

Уравнение реакции

Dimethyl fumarate

5-ethoxyoxazole

→

title compound

3,4-Dimethoxycarbonyl-5-hydroxypyridine

Условия реакции

Обработка

1. 1
   Другоеthe mixture was reacted at 120° C. for 1.5 hours
2. 2
   ДругоеThe reaction residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane 2:1)

Методика

Dimethyl fumarate (781 mg; 1.1 eq.) was added to 5-ethoxyoxazole (557.3 mg; 4.9 mmol), and the mixture was reacted at 120° C. for 1.5 hours. The reaction residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane 2:1), to give crude crystals of the title compound. Yield: 730 mg (70.2%). The crude crystals were recrystallized from dichloromethane-hexane, to give colorless plates.

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