Реакция #65729

Уравнение реакции

(±)-3-(1-methyl-2-pyrrolidinyl)-2-pyridone

2,3,4,6-tetra-O-acetylglucopyranosyl bromide

aluminum

→

(±)-3-(1-methyl-2-pyrrolidinyl)-2-pyridyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ФильтрацияSolid material was filtered off
2. 2
   Концентрированиеthe filtrate was concentrated under reduced pressure

Методика

(±)-3-(1-methyl-2-pyrrolidinyl)-2-pyridone (1)(2.0 g) and 2,3,4,6-tetra-O-acetylglucopyranosyl bromide (4a)(5.6 g) were dissolved in dichloromethane (40 ml). To this solution, silver carbonate (1.8 g) was added. The mixture was stirred at room temperature for 24 hours while the vessel was shielded from light by an aluminum sheet. Solid material was filtered off, and the filtrate was concentrated under reduced pressure. As a result, (±)-3-(1-methyl-2-pyrrolidinyl)-2-pyridyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside (5a) was obtained. The compound (5a) obtained as above was subjected to the experiment of the following example without purification.

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