Реакция #657275

Уравнение реакции

[2-(2,6-Dimethyl-piperidin-1-yl)acetylamino]-acetic acid

N-Hydroxysuccinimide

N,N′-Dicyclohexyl-carbodiimide

→

[2-(2,6-Dimethyl-piperidin-1-yl)acetylamino]-acetic acid-(2,5-dioxo-pyrrolidine-1-yl)-ester

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ФильтрацияThe solution was filtered
2. 2
   Другоеthe filtrate was evaporated in vacuo to dryness
3. 3
   workup.DISSOLUTIONThe residue was dissolved in 50 mL dichloromethane
4. 4
   workup.ADDITIONtreated with charcoal
5. 5
   ФильтрацияAfter filtration
6. 6
   Другоеthe solution was evaporated in vacuo to dryness
7. 7
   Другоеthe product was recrystallised from ethyl acetate

Методика

4.54 g (20 mMol) [2-(2,6-Dimethyl-piperidin-1-yl)acetylamino]-acetic acid (30) were added to 2.30 g (20 mMol) N-Hydroxysuccinimide and 4.12 g (20 mMol) N,N′-Dicyclohexyl-carbodiimide dissolved in 150 ml dichloromethane. The reaction mixture was stirred for 16 h at room temperature. The solution was filtered and the filtrate was evaporated in vacuo to dryness. The residue was dissolved in 50 mL dichloromethane and treated with charcoal. After filtration, the solution was evaporated in vacuo to dryness and the product was recrystallised from ethyl acetate.

Источник