Реакция #657260

Уравнение реакции

trimethyl-3,4,5-pyrazoletricarboxylate

pyrazole

sodium hydride

trityl chloride

→

title compound

Выход 90.0%

Trimethyl 1-trityl-3,4,5-pyrazoletricarboxylate

Выход 90.0%

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   ДругоеThe synthesis of this compound
2. 2
   ДругоеAfter removal of the solvent under vacuum
3. 3
   Промывкаthe resulting residue was washed with distilled water, n-hexane
4. 4
   Другоеfinally dried under vacuum

Методика

The synthesis of this compound was done by tritylation of trimethyl-3,4,5-pyrazoletricarboxylate (1680 mg, 6.94 mmol) using a procedure similar to the one described in examples 2 and 3 for the synthesis of other tritylated pyrazole derivatives. The starting pyrazole reacted with sodium hydride (405 mg, 10.13 mmol) in dry dimethylformamide (80 mL) for 30 min at room temperature. Then, trityl chloride (1935 mg, 6.94 mmol) was added and the reaction mixture stirred overnight at room temperature. After removal of the solvent under vacuum, the resulting residue was washed with distilled water, n-hexane, and finally dried under vacuum to afford the title compound, as a white microcrystalline solid. Yield: 90% (3.034 g, 6.26 mmol).

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