Реакция #65726

Уравнение реакции

hydrazine hydrate

water

2-chloro-5-nitropyridine

→

2-Hydrazino-5-Nitropyridine

Выход 77.3%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ДругоеThe precipitate was isolated by filtration
2. 2
   Промывкаthe solid was washed with methanol
3. 3
   Другоеether to give a green solid
4. 4
   ДругоеThe product was used without further purification

Методика

To a stirred solution of hydrazine hydrate (30.0 equivalents), water (4 ml/gm of pyridine), and ethanol (2 ml/gm of pyridine) was added 2-chloro-5-nitropyridine (1 equivalent). The reaction mixture was stirred at 20° for 16 hours (a very thick green slurry forms). The precipitate was isolated by filtration and the solid was washed with methanol and then ether to give a green solid. The product was used without further purification; yield 77.3%; m.p. 205°-207°. IR {KBr): 3340, 3200, 2980, 1670, 1605, 1580, 1485, 1420, 1330, 1300, 1120, 980, 830, 770 cm-1.

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