Реакция #657257

Уравнение реакции

1-trityl-4-ethoxymethylpyrazole

→

4-ethoxymethylpyrazole

Выход 44.0%

Растворители

ethanol acetone

HCl

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added to the resulting solution
2. 2
   ТемператураAfter cooling to room temperature
3. 3
   Фильтрацияthe reaction mixture was filtered
4. 4
   Промывкаwashed with dichloromethane
5. 5
   Экстракцияextracted with dichloromethane
6. 6
   Сушкаdried over MgSO4
7. 7
   Другоеthe solvent was evaporated under vacuum

Методика

1-trityl-4-ethoxymethylpyrazole (1.800 g, 4.88 mmol) was dissolved in a mixture of ethanol/acetone (15 ml/5 ml) and 30 mL of 2N HCl was added to the resulting solution. The mixture was heated at 80° C. for 2 h. After cooling to room temperature, the reaction mixture was filtered and washed with dichloromethane. The aqueous layer was basified with 2N NaOH and extracted with dichloromethane. The organic layers were combined, dried over MgSO4 and the solvent was evaporated under vacuum yielding compound 4-ethoxymethylpyrazole as a white oil. Yield: 44% (270 mg, 2.14 mmol).

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