Реакция #656406

Уравнение реакции

7,7-dichloro-4-(5-ethoxyheptyl)bicyclo [3.2.0] heptan-6-one

3-heptylcyclopentene

trichloroacetyl chloride

phosphorous oxychloride

→

7,7-dichloro-4-heptylbicyclo[3.2.0]heptan-6-one

Растворители

ether

zinc copper

ether

Условия реакции

Обработка

1. 1
   workup.DISTILLATIONThe crude product is submitted to short path distillation
2. 2
   workup.DISTILLATIONsubsequently fractionally distilled under reduced pressure

Методика

The next procedure followed is that of the preceding Example for the preparation of 7,7-dichloro-4-(5-ethoxyheptyl)bicyclo [3.2.0] heptan-6-one, substituting 3-heptylcyclopentene (49 g, 0.30 moles) diluted in ether (490 ml), trichloroacetyl chloride (97 g, 0.53 moles) and phosphorous oxychloride (81 g, 0.53 moles) both diluted with ether (150 ml), zinc/copper couple (30 g, 0.59 moles) were used. The crude product is submitted to short path distillation and subsequently fractionally distilled under reduced pressure, leaving a clear, colorless oil of 7,7-dichloro-4-heptylbicyclo[3.2.0]heptan-6-one (20.6 g, 0.075 moles), BP 115° C./0.22 mm.

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