Реакция #656402

Уравнение реакции

dimethyloxosulfonium methylide

4-(5-Methoxyheptyl)bicyclo[3.2.0]heptan-6-one

→

4-(5-Methoxyheptyl)spiro[bicyclo[3.2.0]heptane-6,2'-oxirane]

Растворители

dimethyl sulfoxide

Условия реакции

Обработка

1. 1
   ДругоеA 250 ml, 3-necked round bottomed flask is equipped with a magnetic stirrer
2. 2
   Температураmaintained with an oil
3. 3
   workup.ADDITIONfilled bubbler
4. 4
   Другоеa sample is removed

Методика

A 250 ml, 3-necked round bottomed flask is equipped with a magnetic stirrer. The reaction is conducted under a positive nitrogen pressure, maintained with an oil filled bubbler. The reaction vessel is charged with dimethyloxosulfonium methylide (36 ml of 0.932M solution, 0.034 moles) in dimethyl sulfoxide. 4-(5-Methoxyheptyl)bicyclo[3.2.0]heptan-6-one (7.7 g, 0.032 moles) is added neat to the stirring solution by a syringe. The reaction vessel is heated in a 40° C. water bath for 60 minutes and then a sample is removed and analyzed by infra-red spectroscopy.

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