Реакция #65586

Уравнение реакции

1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho p-toluenesulfonate

triethylamine

thiotetronic acid

cyclododecylbutanoic acid

→

white solid

Выход 33.4%

3-(4-cyclododecyl-1-oxobutyl)-4-hydroxy-2-(5H)thiophenone

Выход 33.4%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   workup.STIRRINGAfter stirring for 10 minutes
2. 2
   Температураto warm to room temperature
3. 3
   workup.STIRRINGis stirred overnight
4. 4
   ДругоеThe reaction mixture is quenched with 1N HCl
5. 5
   ДругоеThe layers are separated
6. 6
   Промывкаthe aqueous phase is washed once with dichloromethane
7. 7
   ПромывкаThe combined organic layers are washed twice with aqueous sodium bicarbonate and twice with aqueous 2N HCl
8. 8
   СушкаThe organic phase is then dried over MgSO4
9. 9
   Другоеthe dichloromethane evaporated
10. 10
    Другоеchromatographed on acidic silica gel using 8% ether/hexanes
11. 11
    workup.DISSOLUTIONdissolved in ether
12. 12
    Промывкаwashed with 1N HCl
13. 13
    Другоеdried
14. 14
    Другоеevaporated

Методика

To a dry flask under N2 atmosphere at 0° C. is added 1.31 g (11.3 mmol) of thiotetronic acid in 40 mL of dry dichloromethane followed by 1.42 mL (10.2 mmol) of triethylamine and 0.38 g (3.1 mmol) of 4-dimethylaminopyridine. After stirring at 0° C. for 5 minutes, 2.6 g (10.2 mmol) of cyclododecylbutanoic acid is added followed by 4.8 g (11.3 mmol) of 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho p-toluenesulfonate. After stirring for 10 minutes, the reaction mixture is allowed to warm to room temperature and is stirred overnight. The reaction mixture is quenched with 1N HCl. The layers are separated and the aqueous phase is washed once with dichloromethane. The combined organic layers are washed twice with aqueous sodium bicarbonate and twice with aqueous 2N HCl. The organic phase is then dried over MgSO4 and the dichloromethane evaporated. The residue is flash chromatographed on acidic silica gel using 8% ether/hexanes, dissolved in ether, washed with 1N HCl, dried and evaporated to give 1.2 g of a white solid: m.p. 62°-69° C.; IR; NMR (CDCl3) δ 1.2-1.4 (m, 10H), 1.5 (s, 4H), 1.65 (m, 2H), 2.9 (t, 2H, J=7 Hz), 3.96 and 3.75 (s, 2H); MS

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