Реакция #65572

Уравнение реакции

2-tert-butyl-6-methylaniline

N-methyl-N-(2-phenylcyclohexyl)carbamoylchloride

→

N-(2-tert-butyl-6-methylphenyl)-N'-methyl-N'-(2-phenylcyclohexyl)urea

Растворители

pyridine

dichloromethane

Условия реакции

Обработка

1. 1
   КонцентрированиеThe mixture is concentrated
2. 2
   workup.DISSOLUTIONthe residue is dissolved in ethyl ether
3. 3
   ПромывкаThe solution is washed with diluted hydrochloric acid, aqueous sodium hydrogencarbonate solution and brine
4. 4
   СушкаThe organic layer is dried over sodium sulfate
5. 5
   Фильтрацияfiltered off
6. 6
   workup.DISTILLATIONThe filtrate is distilled away
7. 7
   Другоеthe resuling residue is crystallized

Методика

To a solution of 0.82 g of 2-tert-butyl-6-methylaniline in pyridine is added a solution of 1.2 g of N-methyl-N-(2-phenylcyclohexyl)carbamoylchloride in dichloromethane dropwise. The mixture is stirred at room temperature until starting compounds disappear on TLC. The mixture is concentrated and the residue is dissolved in ethyl ether. The solution is washed with diluted hydrochloric acid, aqueous sodium hydrogencarbonate solution and brine. The organic layer is dried over sodium sulfate and filtered off. The filtrate is distilled away and the resuling residue is crystallized to give N-(2-tert-butyl-6-methylphenyl)-N'-methyl-N'-(2-phenylcyclohexyl)urea.

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