Реакция #65308

Уравнение реакции

6-aminohexan-1-ol

1,2,4-benzenetricarboxylic anhydride

→

1,3-Dioxo-2-(6-hydroxyhex-1-yl)-isoindole-5-carboxylic acid

Растворители

H2O

water

Условия реакции

Обработка

1. 1
   Другоеto give a white crystalline solid
2. 2
   ФильтрацияThe solid was collected by vacuum filtration
3. 3
   Другоеdried overnight in vacuo
4. 4
   Другоеto give 9.1 g (78%) of analytically pure 27

Методика

A mixture of 6-aminohexan-1-ol (11.7 g, 10 mmol) and 1,2,4-benzenetricarboxylic anhydride (7.68 g, 4 mmol) was heated to 175°-225° C. for 15 min or until evolution of H2O vapor stops. The melt was poured into water to give a white crystalline solid. The solid was collected by vacuum filtration and dried overnight in vacuo to give 9.1 g (78%) of analytically pure 27.

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