Реакция #65230

Уравнение реакции

3-(4-aminobutyl)-5-indolylurea

N,N-bis(2-chloroethyl)-o-cyanoaniline

→

3-[4-(4-o-Cyanophenylpiperazino)butyl]-5-indolylurea, hydrochloride

Растворители

acetone

water

Условия реакции

Методика

A mixture of 2.87 g of 3-(4-aminobutyl)-5-indolylurea [obtainable from 5-indolylurea via 3-(4-chlorobutyryl)-5-indolylurea, 3-(4-chlorobutyl) -5-indolylurea and 3-(4-phthalimidobutyl)-5-indolylurea] and one equivalent of N,N-bis(2-chloroethyl)-o-cyanoaniline ("C") in 40 ml of acetone and 40 ml of water is boiled for 24 hours and worked up in a conventional manner. 3-[4-(4-o-Cyanophenylpiperazino)butyl]-5-indolylurea, hydrochloride, m.p. 164°-166° is obtained.

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