Реакция #65206

Уравнение реакции

6-(2-chlorobenzoyl)-5-(2-chlorobenzoylamino)indan

ammonia

→

5-amino-6-(2-chlorobenzoyl)indan

Выход 94.4%

Растворители

H2SO4

—

ice water

Условия реакции

Обработка

1. 1
   Экстракцияextracted with ethyl acetate
2. 2
   ПромывкаThe extract was washed with water
3. 3
   Сушкаdried (MgSO4)
4. 4
   workup.DISTILLATIONthe solvent was distilled off

Методика

A mixture of 6-(2-chlorobenzoyl)-5-(2-chlorobenzoylamino)indan (16.0 g) and 70% H2SO4 (100 ml) was heated at 120° C. for 30 minutes and, then, poured in ice-water (300 ml). The solution was alkalinized with concentrated aqueous ammonia and extracted with ethyl acetate. The extract was washed with water and dried (MgSO4) and the solvent was distilled off to give 5-amino-6-(2-chlorobenzoyl)indan as yellow oil (10.0 g, 94.3%). Recrystallization from hexane gave yellow prisms, m.p. 90°-92°.

Источник