Реакция #65152

Уравнение реакции

3-bromo-3,4-dihydro-2,2-dimethyl-6-pentafluoroethyl-2H-1-benzopyran-4-ol

potassium hydroxide

→

3,4-dihydro-2,2-dimethyl-3,4-epoxy-6-pentafluoroethyl-2H-1-benzopyran

Выход 96.2%

Растворители

diethyl ether

Условия реакции

Обработка

1. 1
   Другоеsynthesized
2. 2
   workup.ADDITIONwas added
3. 3
   ДругоеThe insoluble material was removed by filtration
4. 4
   Другоеthe solvent was removed by distillation under reduced pressure

Методика

To 1.5 l of diethyl ether was added 12.63 g (33.67 mmol) of 3-bromo-3,4-dihydro-2,2-dimethyl-6-pentafluoroethyl-2H-1-benzopyran-4-ol synthesized according to the process of JP-B-2-237985, and 30.2 g of potassium hydroxide was added thereto, followed by stirring at room temperature for 54 hours. The insoluble material was removed by filtration, and the solvent was removed by distillation under reduced pressure to yield 9.5 g (96.2%) of 3,4-dihydro-2,2-dimethyl-3,4-epoxy-6-pentafluoroethyl-2H-1-benzopyran.

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