Реакция #65095

Уравнение реакции

4-bromophenol

n-octylbromide

potassium carbonate

→

4-bromo-1-n-octyloxybenzene

Выход 63.9%

Растворители

acetone

Условия реакции

Обработка

1. 1
   Температураto reflux for 12 hours
2. 2
   workup.DISTILLATIONAfter the solvent was distilled off under a reduced pressure
3. 3
   Другоеthe residue thus obtained
4. 4
   Экстракцияwas extracted with isopropyl ether
5. 5
   Промывкаwashed with a 5% aqueous sodium hydroxide solution and water in turn
6. 6
   workup.DISTILLATIONThe ether was distilled off
7. 7
   Другоеthe residue was purified by a silica gel column chromatography
8. 8
   workup.DISTILLATIONsubjected to distillation

Методика

In 100 ml of acetone, 8.0 g of 4-bromophenol, 8.9 g of n-octylbromide, and 13 g of potassium carbonate were heated to reflux for 12 hours. After the solvent was distilled off under a reduced pressure, the residue thus obtained was extracted with isopropyl ether, washed with a 5% aqueous sodium hydroxide solution and water in turn. The ether was distilled off, and the residue was purified by a silica gel column chromatography using a mixed solvents of n-hexane and diethyl ether (10:1) and subjected to distillation to obtain 8.4 g of 4-bromo-1-n-octyloxybenzene.

Источник