Реакция #65089

Уравнение реакции

2-(5-tetrahydropyranyloxy-3-pentyl)cyclopropylmethyl t-butyldimethylsilyl ether

tetrahydrofuran

tetrabutyl ammonium fluoride

→

2-(5-tetrahydropyranyloxy-3-pentynyl)cyclopropanemethanol

Условия реакции

Обработка

1. 1
   workup.DISTILLATIONThe solvent was distilled off
2. 2
   Другоеthe product was purified by silica gel column chromatography

Методика

The 2-(5-tetrahydropyranyloxy-3-pentyl)cyclopropylmethyl t-butyldimethylsilyl ether (3 g, 10 mmol) was dissolved in tetrahydrofuran (10 ml), and tetrabutyl ammonium fluoride (factor=1.0, 12 ml, 12 mmol) was added at 0° C. The mixture was stirred for 30 minutes. The solvent was distilled off, and the product was purified by silica gel column chromatography to obtain 2-(5-tetrahydropyranyloxy-3-pentynyl)cyclopropanemethanol (1.2 g)

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