Реакция #64972

Уравнение реакции

7-acetyl-1,2-dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane

NaOH

K2CO3

→

1,2-Dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane

Растворители

water

Условия реакции

Обработка

1. 1
   Экстракцияextracted several times with CHCl3
2. 2
   Сушкаthe extract is dried over K2CO3
3. 3
   Концентрированиеconcentrated
4. 4
   workup.DISTILLATIONthe residue is distilled

Методика

11.8 g (64mmol) of 7-acetyl-1,2-dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane are heated under reflux with 12 g of NaOH in 36 ml of water overnight. The mixture is saturated with K2CO3 and extracted several times with CHCl3, the extract is dried over K2CO3 and concentrated and the residue is distilled.

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