Реакция #64955

Уравнение реакции

3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane

benzylmethylamine

→

trans-1-Benzyl-3-benzylmethylamino-4-hydroxypyrrolidine

Растворители

dioxane

water

Условия реакции

Обработка

1. 1
   ЭкстракцияThe mixture is extracted with CHCl3
2. 2
   Сушкаthe extracts are dried with K2CO3
3. 3
   Концентрированиеconcentrated
4. 4
   workup.DISTILLATIONdistillation up to 160° C. (oil bath temperature)

Методика

19.4 g (0.1 mol) of 90% strength 3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane are heated under reflux with 14.5 g (0.12 mol) of benzylmethylamine in 100 ml of dioxane and 200 ml of water overnight. The mixture is extracted with CHCl3, the extracts are dried with K2CO3 and concentrated and the residue is subjected to incipient distillation up to 160° C. (oil bath temperature).

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