Реакция #64935

Уравнение реакции

1-benzyl-4-hydroxy-3-(2-hydroxyethylamino)-pyrrolidine

sodium hydroxide

→

8-Benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane

Растворители

sulphuric acid

water

Условия реакции

Обработка

1. 1
   Другоеthe sodium sulphate which has precipitated
2. 2
   Фильтрацияis filtered off with suction
3. 3
   Экстракцияthe filtrate is extracted with chloroform
4. 4
   СушкаThe extract is dried over potassium carbonate
5. 5
   Концентрированиеconcentrated
6. 6
   workup.DISTILLATIONthe residue is distilled

Методика

15.6 g (66mmol) of 1-benzyl-4-hydroxy-3-(2-hydroxyethylamino)-pyrrolidine are heated under reflux in a mixture of 60 ml of concentrated sulphuric acid and 20 ml of water for 6 hours. The mixture is rendered alkaline with concentrated sodium hydroxide solution, the sodium sulphate which has precipitated is filtered off with suction and the filtrate is extracted with chloroform. The extract is dried over potassium carbonate and concentrated and the residue is distilled.

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