Реакция #649055

Уравнение реакции

3-(methylthio)propan-1-ol

Hunig's base

methanesulfonyl chloride

→

title compound

3-(Methylthio)propyl methanesulfonate

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ДругоеThe resulting reaction mixture
2. 2
   Температураwarmed slowly to RT
3. 3
   ДругоеThe reaction was quenched with sat. aq. NH4Cl
4. 4
   Экстракцияextracted with ether
5. 5
   ПромывкаThe combined organic extracts were washed with water and brine
6. 6
   Сушкаdried over MgSO4
7. 7
   Фильтрацияfiltered
8. 8
   КонцентрированиеConcentrated of the filtrate in vacuo

Методика

To a solution of 3-(methylthio)propan-1-ol in dichloromethane (0.2 M) was added sequentially at −78° C. Hunig's base (1.3 eq.) and methanesulfonyl chloride (1.3 eq.). The resulting reaction mixture was stirred at −78° C. for 1 h and then warmed slowly to RT. The reaction was quenched with sat. aq. NH4Cl and then extracted with ether. The combined organic extracts were washed with water and brine, dried over MgSO4, and filtered. Concentrated of the filtrate in vacuo afforded the title compound as a yellow oil.

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