Реакция #64780

Уравнение реакции

bis(trimethylsilyl)trifluoroacetamide

L-aspartic acid

2-trifluoromethyl-3-acetylthiopropionyl chloride

dimethylformamide

→

title compound

N-[2-[(Acetylthio)methyl]-3,3,3-trifluoro-1-oxopropyl]-L-aspartic acid

Растворители

acetonitrile

acetonitrile

Условия реакции

Обработка

1. 1
   Температураgradually warmed to room temperature overnight
2. 2
   workup.STIRRINGthe mixture was stirred for 2 hours
3. 3
   ТемператураThe resultant clear, light yellow solution was cooled to 5° C.
4. 4
   workup.ADDITIONwas added dropwise
5. 5
   workup.STIRRINGto stir
6. 6
   Температураwarm to room temperature overnight
7. 7
   Другоеthe solvent was evaporated
8. 8
   ДругоеThe yellow syrupy residue was partitioned between water (50 mL) and ethyl acetate (50 mL)
9. 9
   Другоеthe organic layer was separated
10. 10
    ЭкстракцияThe aqueous phase was further extracted with ethyl acetate (3×50 mL)
11. 11
    Экстракцияthe combined ethyl acetate extract
12. 12
    Промывкаwas washed with brine
13. 13
    Сушкаdried (MgSO4)
14. 14
    Другоеevaporated
15. 15
    Другоеto yield 12.2 g
16. 16
    ПромывкаFlash chromatography on silica gel (125:1 silica gel to compound) eluting with ethyl acetate
17. 17
    Другоеacetic acid, 15:1 gave 5.25 g

Методика

A stirred suspension of L-aspartic acid (2.66 g., 20 mmol.) in 35 mL of dry acetonitrile under argon was cooled to 0° C. and bis(trimethylsilyl)trifluoroacetamide (10.62 mL, 40 mmol) was added. The reaction mixture was allowed to stir and gradually warmed to room temperature overnight, and then 5 mL of dimethylformamide was added and the mixture was stirred for 2 hours. The resultant clear, light yellow solution was cooled to 5° C. and 2-trifluoromethyl-3-acetylthiopropionyl chloride (4.69 g., 20 mmol), dissolved in 6 mL of acetonitrile, was added dropwise. The reaction mixture was allowed to stir and warm to room temperature overnight, and then the solvent was evaporated. The yellow syrupy residue was partitioned between water (50 mL) and ethyl acetate (50 mL), and the organic layer was separated. The aqueous phase was further extracted with ethyl acetate (3×50 mL) and the combined ethyl acetate extract was washed with brine, dried (MgSO4) and evaporated to yield 12.2 g. of a light yellow residue. Flash chromatography on silica gel (125:1 silica gel to compound) eluting with ethyl acetate:acetic acid, 15:1 gave 5.25 g. of a major fraction which was a light yellow sticky solid and 0.63 g. fraction which was nearly homogeneous by TLC, for a total of 5.88 g. of the title compound as a mixture of diastereomers.

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