Реакция #64426

Уравнение реакции

1-bromopentane

3-Bromophenol

potassium carbonate

→

3-bromo-phenol

n-pentyl ether

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   Температураcooled to room temperature
2. 2
   Фильтрацияfiltered
3. 3
   workup.ADDITIONThe filtrate is diluted with ether
4. 4
   Промывкаwashed with water and brine
5. 5
   СушкаAfter drying over magnesium sulfate
6. 6
   Концентрированиеconcentrating
7. 7
   Другоеthe crude oil obtained
8. 8
   Другоеis chromatographed over silica gel
9. 9
   Промывкаeluted with 3:2 hexane

Методика

To a solution of 5.0 gm of 3-Bromophenol in 60 mls of dimethylformamide is added 6.0 gm of potassium carbonate followed by 4.3 ml of 1-bromopentane. This mixture is heated to 60° C. for 6 hours and then cooled to room temperature and filtered. The filtrate is diluted with ether and washed with water and brine. After drying over magnesium sulfate and concentrating, the crude oil obtained is chromatographed over silica gel, and eluted with 3:2 hexane:ether to yield 3-bromo-phenol, n-pentyl ether as a clear oil.

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