Реакция #641157

Уравнение реакции

hydrogen

(3S,8aR)-3-(2,4,6-trifluorophenyl)-2,3,6,8a-tetrahydro-1H-indolizin-5-one

→

title compound

Выход 99.6%

(3S,8aR)-3-(2,4,6-trifluorophenyl)hexahydroindolizin-5-one

Выход 99.6%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ФильтрацияThe reaction solution was filtered through celite
2. 2
   Концентрированиеthe filtrate was concentrated under reduced pressure

Методика

Platinum oxide (25 mg) was added to a solution of (3S,8aR)-3-(2,4,6-trifluorophenyl)-2,3,6,8a-tetrahydro-1H-indolizin-5-one (548 mg) in methanol (5 mL), and the reaction solution was stirred in a hydrogen atmosphere at 1 atm at room temperature for one hour. The reaction solution was filtered through celite, and the filtrate was concentrated under reduced pressure to obtain 550 mg of the title compound. The property value of the compound is as follows.

Источник