Реакция #640581

Уравнение реакции

5,5-Dimethyl-3-(2-nitrobenzyl)-[1,3]-oxazinan-2-thione

ammonium chloride

water

→

3-(2-aminobenzyl)-5,5-dimethyl-[1,3]-oxazinan-2-thione

Выход 63.2%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураto reflux for one hour
2. 2
   Фильтрацияthe reaction mixture was filtered with suction
3. 3
   Экстракцияextracted with ethyl acetate
4. 4
   ПромывкаThe organic layer was washed with a saturated brine
5. 5
   Сушкаdried over anhydrous sodium sulfate
6. 6
   Другоеthe solvent was evaporated under reduced pressure

Методика

5,5-Dimethyl-3-(2-nitrobenzyl)-[1,3]-oxazinan-2-thione (1.06 g, 3.79 mmol), iron powder (1.06 g, 19.0 mmol), ammonium chloride (0.10 g, 1.87 mmol) were suspended in ethanol (20 ml) and water (10 ml) and heated to reflux for one hour. After cooling to room temperature, the reaction mixture was filtered with suction and extracted with ethyl acetate. The organic layer was washed with a saturated brine and then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to obtain 3-(2-aminobenzyl)-5,5-dimethyl-[1,3]-oxazinan-2-thione (0.60 g).

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