Реакция #640575

Уравнение реакции

3-(2-Nitrobenzyl)-6-phenyl-[1,3]-oxazinan-2-one

ammonium chloride

water

→

3-(2-aminobenzyl)-6-phenyl-[1,3]-oxazinan-2-one

Выход 99.3%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураto reflux for 1.5 hours
2. 2
   Фильтрацияthe reaction mixture was filtered with suction
3. 3
   Экстракцияextracted with ethyl acetate
4. 4
   ПромывкаThe organic layer was washed with a saturated brine
5. 5
   Сушкаdried over anhydrous sodium sulfate

Методика

3-(2-Nitrobenzyl)-6-phenyl-[1,3]-oxazinan-2-one (1.59 g, 5.10 mmol), iron powder (1.42 g, 25.4 mmol), ammonium chloride (0.14 g, 2.62 mmol) were suspended in ethanol (30 ml) and water (15 ml) and heated to reflux for 1.5 hours. After cooling to room temperature, the reaction mixture was filtered with suction and extracted with ethyl acetate. The organic layer was washed with a saturated brine and then dried over anhydrous sodium sulfate, and 3-(2-aminobenzyl)-6-phenyl-[1,3]-oxazinan-2-one (1.43 g) was obtained by evaporating the solvent under reduced pressure.

Источник