Реакция #640559

Уравнение реакции

Phenyl pyruvic acid

oxaloacetic acid

potassium hydroxide

hydrochloric acid

→

4-phenylmethyl-4-hydroxy-2-ketoglutaric acid

Выход 37.0%

Условия реакции

Обработка

1. 1
   workup.DISSOLUTIONhad been dissolved
2. 2
   Другоеreacted at room temperature for 72 hours
3. 3
   Экстракцияthe reaction mixture was extracted with ethyl acetate
4. 4
   ПромывкаAn organic layer was washed with saturated aqueous NaCl solution
5. 5
   Другоеdried on magnesium sulfate anhydrate
6. 6
   Концентрированиеconcentrated
7. 7
   Другоеto yield residue
8. 8
   ДругоеThe residue was recrystallized from ethyl acetate and toluene

Методика

Phenyl pyruvic acid (5.0 g, 30.5 mmol) and 12.1 g (91.4 mmol) of oxaloacetic acid were added to 25 mL of aqueous solution in which 13.8 g of potassium hydroxide (purity 85%) had been dissolved, and reacted at room temperature for 72 hours. A pH value of the reaction mixture was adjusted to 2.2 using concentrated hydrochloric acid, and the reaction mixture was extracted with ethyl acetate. An organic layer was washed with saturated aqueous NaCl solution, dried on magnesium sulfate anhydrate, and then concentrated to yield residue. The residue was recrystallized from ethyl acetate and toluene to yield 2.8 g (11.3 mmol) of 4-phenylmethyl-4-hydroxy-2-ketoglutaric acid as crystal.

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