Реакция #640541

Уравнение реакции

6-aminonicotinic acid

ethanol

→

white solid

Ethyl 6-Aminonicotinate

Условия реакции

Обработка

1. 1
   Другоеwas bubbled in dry hydrochloric acid at 0° C.
2. 2
   Температураthe solution was refluxed until all the solids
3. 3
   workup.DISSOLUTIONdissolved
4. 4
   ДругоеThe solvents were removed under reduced pressure
5. 5
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
6. 6
   Промывкаwashed with saturated sodium bicarbonate, brine
7. 7
   Концентрированиеconcentrated

Методика

To a suspension of 1.3 g (9.4 mmol) 6-aminonicotinic acid in 100 mL of ethanol, was bubbled in dry hydrochloric acid at 0° C., then the solution was refluxed until all the solids dissolved. The solvents were removed under reduced pressure, the residue dissolved in ethyl acetate, washed with saturated sodium bicarbonate, brine and concentrated to afford 1.37 g of a white solid, m/e=166(M+H).

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