Реакция #640539

Уравнение реакции

2,6-Dimethylaniline

ethyl bromoacetate

N-(2,6-Dimethylphenyl)glycine hydrobromide salt

→

N-(2,6 Dimethylphenyl)glycine

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ДругоеA precipitated
2. 2
   Другоеformed which
3. 3
   Другоеwas collected
4. 4
   Другоеtriturated with dichloromethane (25 mL)

Методика

2,6-Dimethylaniline (6.1 g, 50.4 mmol), and ethyl bromoacetate (8.4 g, 50.4 mmol) were refluxed neat for 10 min. The reaction mixture was cooled to room temperature and poured into dichloromethane (75 mL). A precipitated formed which was collected and triturated with dichloromethane (25 mL). N-(2,6-Dimethylphenyl)glycine hydrobromide salt (1.21 g, 4.6 mmol, 9.0%) was collected as a white crystalline solid. 1H NMR (CD3OD) d 2.48 (s, 6H), 4.29 (s, 2H), 7.00-7.10 (m, 3H).

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