Реакция #640532

Уравнение реакции

4-(1H-benzimidazol-2-yl)-furazan-3-ylamine

potassium carbonate

4-chloro-3-nitrophenacyl bromide

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title compound

4-[1-(4-Chloro-3-nitrophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

Растворители

DMF

ethyl acetate

Условия реакции

Обработка

1. 1
   Промывкаwashed with water
2. 2
   Сушкаdried over sodium sulphate
3. 3
   ФильтрацияFiltration of the sodium sulphate, concentration of the filtrate under reduced pressure and chromatography of the residue on silicagel

Методика

A suspension of 4-(1H-benzimidazol-2-yl)-furazan-3-ylamine (0.228 g, 1.14 mmol), potassium carbonate (0.40 g, 2.85 mmol) and 4-chloro-3-nitrophenacyl bromide (0.35 g, 1.25 mmol) in DMF (5 ml) is stirred at room temperature for 16 hours. The reaction mixture is diluted with ethyl acetate, washed with water and dried over sodium sulphate. Filtration of the sodium sulphate, concentration of the filtrate under reduced pressure and chromatography of the residue on silicagel using hexane-ethyl acetate as eluent gives the title compound as a solid, m.p. 198-200° C. (This compound is also listed as Example 66 in Table 1.)

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