Реакция #640522

Уравнение реакции

4-(1H-benzimidazol-2-yl)-furazan-3-ylamine

potassium carbonate

iodomethoxy benzene

→

title compound

4-(1-Phenoxymethyl-1H-benzimidazol-2-yl)-furazan-3-ylamine

Условия реакции

Обработка

1. 1
   ДругоеEvaporation of the solvent under reduced pressure
2. 2
   Другоеpartitioning of the resulting residue between water and ethyl acetate
3. 3
   Сушкаby drying of the organic solution over sodium sulphate and chromatography of the residue

Методика

To a solution of 4-(1H-benzimidazol-2-yl)-furazan-3-ylamine (0.10 g, 0.497 mmol) is added potassium carbonate (0.172 g, 1.24 mmol) and iodomethoxy benzene (0.128 g, 0.546 mmol). The mixture is stirred over night. Evaporation of the solvent under reduced pressure and partitioning of the resulting residue between water and ethyl acetate followed by drying of the organic solution over sodium sulphate and chromatography of the residue gives the title compound as a colorless solid, m.p. 171-173° C.

Источник