Реакция #640517

Уравнение реакции

4-[1-(4-bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

sodium bicarbonate

hydroxylamine hydrochloride

→

title compound

4-[1-(4-Bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine oxime

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураis refluxed for 20 hours
2. 2
   ДругоеPartitioning of the reaction mixture between ethyl acetate and water, separation of the organic phase
3. 3
   Другоеby drying
4. 4
   Другоеevaporation of the solvent
5. 5
   Другоеgives the crude product
6. 6
   ДругоеPurification by chromatography on silicagel

Методика

A mixture of 4-[1-(4-bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine (0.083 g, 0.21 mmol, prepared according to Example 1), sodium bicarbonate (0.021 g, 0.25 mmol) and hydroxylamine hydrochloride (0.014 g, 0.21 mmol) in ethanol (5 ml) is refluxed for 20 hours. Partitioning of the reaction mixture between ethyl acetate and water, separation of the organic phase followed by drying and evaporation of the solvent gives the crude product. Purification by chromatography on silicagel yields the title compound as an E/Z-mixture, m.p. 198-201° C.

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