Реакция #63979

Уравнение реакции

hydrochloric acid

1-(3,4-dichlorophenyl)-1-cyclobutanecarbonitrile

propyl magnesium bromide

ether

propyl bromide

magnesium

ether

ether

→

1-butyryl-1-(3,4-dichlorophenyl)cyclobutane

Растворители

toluene

Water

Условия реакции

Обработка

1. 1
   Температураthe mixture heated
2. 2
   Температураunder reflux for one hour
3. 3
   Температураthe mixture heated
4. 4
   Температураunder reflux for one hour
5. 5
   ЭкстракцияThe reaction mixture was extracted with ether
6. 6
   Промывкаafter washing
7. 7
   Другоеdrying the extract

Методика

A solution of 1-(3,4-dichlorophenyl)-1-cyclobutanecarbonitrile prepared as described in Example 1 (35.2 g) in ether (100 ml) was added to a solution of propyl magnesium bromide prepared by the reaction of propyl bromide (32 g) with magnesium turnings (6.36 g) in ether (100 ml). The ether was replaced by dry toluene and the mixture heated under reflux for one hour. Water (200 ml) and then concentrated hydrochloric acid (120 ml) were added and the mixture heated under reflux for one hour. The reaction mixture was extracted with ether and after washing and drying the extract yielded a residue from which 1-butyryl-1-(3,4-dichlorophenyl)cyclobutane (b.p. 120°-128° C. at 0.25 mm) was distilled.

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