Реакция #63969

Уравнение реакции

1,2-dibromotetrafluoroethane

2-chloro-4-nitrophenol

potassium carbonate

sodium hydroxide

propanethiol

→

3-chloro4-(2-bromo-1,1,2,2-tetrafluoroethoxy)nitrobenzene

Выход 190.0%

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   ДругоеThe pressure bottle was sealed
2. 2
   ТемператураThe pressure bottle was cooled to room temperature
3. 3
   workup.ADDITIONthe contents poured into a separatory funnel
4. 4
   ЭкстракцияThe resultant mixture was extracted with four 300 mL portions of diethyl ether
5. 5
   Промывкаwashed with two 100 mL portions of a 2N sodium hydroxide solution
6. 6
   ЭкстракцияThe washed extract
7. 7
   Сушкаwas dried over anhydrous magnesium sulfate
8. 8
   Фильтрацияfiltered
9. 9
   ДругоеThe filtrate was evaporated under reduced pressure
10. 10
    Другоеleaving an oil
11. 11
    Другоеpurified by column chromatography on silica gel
12. 12
    Промывкаeluting with n-heptane:toluene (95:5)

Методика

Into a pressure bottle was placed 15.0 g (0.086 mole) 2-chloro-4-nitrophenol, 11.9 g (0.086 mole) potassium carbonate, 1.5 g (0.02 mole) propanethiol, 33.7 g (0.13 mole) 1,2-dibromotetrafluoroethane and 115 mL of N,N-dimethylformamide. The pressure bottle was sealed and the mixture stirred at 50° C. for 48 hours. The pressure bottle was cooled to room temperature, opened, and the contents poured into a separatory funnel. Approximately 200 mL of a 2N sodium hydroxide solution was added to the separatory funnel. The resultant mixture was extracted with four 300 mL portions of diethyl ether. The extracts were combined and washed with two 100 mL portions of a 2N sodium hydroxide solution. The washed extract was dried over anhydrous magnesium sulfate and filtered. The filtrate was evaporated under reduced pressure leaving an oil. The reaction described above was repeated three additional times. The residual oils from the four experiments were combined and purified by column chromatography on silica gel, eluting with n-heptane:toluene (95:5), to yield 57.6 g of 3-chloro4-(2-bromo-1,1,2,2-tetrafluoroethoxy)nitrobenzene as an oil.

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