Реакция #63890

Уравнение реакции

water

3-bromopropane

N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide

sodium hydride

→

desired product

N-[3-(3-Methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]-N-propylacetamide

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   workup.STIRRINGThis mixture was stirred for 2.5 days
2. 2
   Экстракцияextracted with 150 ml portions of dichloromethane
3. 3
   Другоеdried
4. 4
   Другоеevaporated in vacuo
5. 5
   ДругоеThe residue was chromatographed

Методика

To 10.0 of N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide in 500 ml of dry dimethylformamide under argon, was added 2.0 g of sodium hydride (50% in oil). This mixture was stirred for 1 hour, then 3.75 ml of 3-bromopropane was added. This mixture was stirred for 2.5 days, then poured into 1 liter of water and extracted with 150 ml portions of dichloromethane. The extracts were combined, dried and evaporated in vacuo. The residue was chromatographed as described in Example 1, giving 3.60 g of the desired product as yellow crystals, mp 145°-149° C.

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