Реакция #63871

Уравнение реакции

N-(3-Hydroxybenzyl)piperidine

6-bromohexanenitrile

potassium carbonate

→

6-(3-piperidinomethylphenoxy)hexanenitrile

Растворители

acetone

Условия реакции

Обработка

1. 1
   ТемператураThe reaction mixture was cooled
2. 2
   Фильтрацияfiltered
3. 3
   ДругоеThe solvent was removed by evaporation
4. 4
   Температураthe residue was heated
5. 5
   Другоеto remove unreacted 6-bromohexanenitrile

Методика

N-(3-Hydroxybenzyl)piperidine (9.55 g) was heated with 6-bromohexanenitrile (10.2 g) and potassium carbonate (13.8 g) under reflux in acetone (150 ml) for 66 hours. The reaction mixture was cooled and filtered. The solvent was removed by evaporation and the residue was heated with stirring at 100° C. for one hour to remove unreacted 6-bromohexanenitrile and to yield 6-(3-piperidinomethylphenoxy)hexanenitrile as an oil.

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