Реакция #638691

ord-1c26ff9dcb044f2c8c07742fcab35fd5

Уравнение реакции

CC(C)(C)OC(=O)n1ccc2ccc(CO)cc21
6-hydroxymethyl-indole-1-carboxylic acid tert-butyl ester
CC(C)(C)OC(=O)n1ccc2c(C=O)cccc21
4-formyl-indole-1-carboxylic acid tert-butyl ester
→
CC(C)(C)OC(=O)n1ccc2c(CO)cccc21
4-Hydroxymethyl-indole-1-carboxylic acid tert-butyl ester

Реактанты

CC(C)(C)OC(=O)n1ccc2ccc(CO)cc21
6-hydroxymethyl-indole-1-carboxylic acid tert-butyl ester
CC(C)(C)OC(=O)n1ccc2c(C=O)cccc21
4-formyl-indole-1-carboxylic acid tert-butyl ester

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

4-Hydroxymethyl-indole-1-carboxylic acid tert-butyl ester was synthesized by a procedure similar to 6-hydroxymethyl-indole-1-carboxylic acid tert-butyl ester from starting material 4-formyl-indole-1-carboxylic acid tert-butyl ester to yield the product as a clear viscous oil (0.91 g, 78%). LC-MS (ES) calculated for C14H17NO3, 247.1; found m/z 246 [M+H]+.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07947728B1uspto-grants-2011_05