Реакция #63647

Уравнение реакции

1-(2-pyrimidinyl)-4-piperazinyl propanol

diphenylmethylbromide

sodium bicarbonate

→

title compound

Выход 26.0%

2-[4-[3-(diphenylmethoxy)propyl]-1-piperazinyl]pyrimidine

Выход 26.0%

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   ТемператураThe reaction mixture was refluxed overnight
2. 2
   Другоеdimethylformamide was evaporated under reduced pressure
3. 3
   Экстракцияthe residue was extracted with methylene chloride (400 ml.)
4. 4
   ДругоеThe methylene chloride extracts were collected
5. 5
   Промывкаwashed with water
6. 6
   Другоеevaporated
7. 7
   Другоеthe remaining residue was purified by HPLC
8. 8
   Другоеto give 1.3 g

Методика

To a stirred solution of 1-(2-pyrimidinyl)-4-piperazinyl propanol 3 g. (0.013 mol) in 50 mol. of dimethylformamide was added 3.3 g. (0.013 mol) of diphenylmethylbromide and 2.9 g. (0.034 mol) of sodium bicarbonate. The reaction mixture was refluxed overnight, dimethylformamide was evaporated under reduced pressure, and the residue was extracted with methylene chloride (400 ml.). The methylene chloride extracts were collected, washed with water and evaporated, and the remaining residue was purified by HPLC to give 1.3 g. (26% yield) of the title compound. The free base which was converted to the (1:1) fumarate salt; m.p 166°-168° C.

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